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Highest Degree |
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Ph.D. from University of Tennessee, Memphis (1991) |
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Specialties |
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Signal transduction
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| Original paper： ( since 1997 ) |
| 01. |
Ho Y.-S., Lee H.-M , Mou T.-C. Wang
I.-J. and Lin J.-K.(1997) Suppression of nitric
oxide induced apoptosis by N-acetyl-L-cysteine
through modulation of glutathione, Bcl-2 and bax
protein levels. Mol. Carcinogene.
19:101-113. (SCI) |
| 02. |
Lee
H.-M
and Huang C.L. (1997) NMDA inhibits carbachol-stimulated
PI resynthesis. Neurochemical Research 22:
607-614. (SCI) |
| 03. |
Pan S.H., Mou D.C., Huang C.L. and Lee H.-M.
(1997) Pentoses react with BSA to form AGEs
faster than hexoses in vitro. J. Chinese
Nutrition Soc. 22: 193-205. |
| 04. |
Pan S.H., Lin Y.H.,Su S.J.and Lee H.-M.
(1997) Immunohistochemical localization of
AGEs in tissues from STZ-induced diabetic rats.
J. Biomed. Lab. Sci. 19: 78-86. |
| 05. |
Lee,
H.-M.
, Tsai K.-J., Lin C.-H., Huang C.-L., amd Tung C.-S.
(1998) Arecoline desensitizes carbachol-stimulated
phosphatidylinositol breakdown in rat cortical
slices. J. Neurochem. 70: 1189-1198.
(SCI) |
| 06. |
Ho Y.-S., Lee, H.-M. , Chang T.R.,
Wang Y-J., Lin J.-K. (1998) Induction of bax protein
and degradation of lamin A during the p53-dependent
apoptosis induced by chemotherapeutic agents in
human cancer cells. Biochem. Pharmacol.
57:143-154. (SCI) |
| 07. |
Lin Y.-F., Wang I.-K., Wu H.-S., Chen C.F., and
Lee, H.-M. (1999) Elevation of
serum advanced glycosylation end products in
diabetic patients. New Taipei J. Med.
1:23-30. |
| 08. |
Wu H.-S. and Lee, H.-M. (1999)
Amphetamine activates protein kinase C in primary
culture of rat brain neuronal cells. New Taipei
J. Med. 1:12-19. |
| 09. |
Chang S.-G., Chien C.-S., Lee H.-M
. and Chen C.-Y. (1999) Interference of selected
clinical medicines on DRU and TDx Immunoassay of
morphine and metamphetamine in urine. J. Food &
Drug Analysis. 7: 259-268. (SCI) |
| 10. |
Chen C.-C., Huang C.-C., Chen
F.-C., Lee
H.-M ., Hsieh M.S. (2000) Factors
influencing HbA1C analyses: Effects of anticoagulats
and hematocrit.
J. Biomed. Lab. Sci. 12: 20-24.
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| 11. |
Lin C,-H., Sheu S.-Y.,
Lee H.-M
. , Ho Y.-S., Lee W.-S., Ko W.-C.,
and Sheu J.-R. (2000) Involvement of PKC- g in IL-1
b induced Cox-2 expression in human pulmonary
epithelial cells.
Mol. Pharmacol.
57:36-43.
(SCI)
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| 12. |
Wang I.-K., Lin J.-K., Ho Y.-S., Yu W.-Y. and
Lee H.-M . (2000) Roles of cyclin
D3 in PMA-induced human leukemic HL-60 cell
apoptosis. J. Genetics and Mol. Biol. 11:
1-11. |
| 13. |
Lin C.-H., Kuan I. -H., Lee H.-M.,
Lee W.-S., Sheu J.-R., Ho Y.-S., Wang C-H., and Kuo
H.-P. (2001). Induction of Cox-2 protein by LTA from
Staphylococcus aureus in human pulmonary epithelial
cells: Involvement of NFkB pathway. Br. J.
Pharmacol. 134:543-552. (SCI) |
| 14. |
Lin C.-H., Lin Y.-F., Chang M.-C., Ho Y.-S., and
Lee H.-M . (2001) Advanced
Glycosylation End Products -Induce Nitric Oxide
Synthase Expression in C6 Glioma Cells: Involvement
of p38 MAP kinase Dependent Mechanisms. Life Sci.
69:2503-2515. (SCI) |
| 15. |
Lin C.-H., Wu C.-H., Thum W.-Y., Ho Y.-S., and
Lee H.-M . (2002) Involvement of
p38 MAP kinase in PLL-AGEs induced cyclooxygenase-2
expression in RAW 254.7 cells. Europ. J.
Pharmacol. 2002; 438(3): 143-52. (SCI) |
| 16. |
Chang M.-S., Lee W.-S., Teng C.-M., Lee H.-M
., Sheu J.-R., Hsiao G., Lin C.-H., (2002)
YC-1 increases cyclooxygenase-2 expression through
protein kinase G- and p42/44 mitogen activated
protein kinase-dependent pathways in A549 cells.
Brit. J. Pharmacol. (In press) (SCI) |
| 17. |
Wu C.-H., Jeng J.-H., Wang Y.-J., Tseng C.-J., Liang
Y.-C., Chen C.-H., Lee H.-M. Lin
J.-K., Ho Y.-S. (2002) Antitumor effects of
miconazole on human colon carcinoma xenograft in
nude mice through induction of apoptosis and Go/G1
cell cycle arrest. Toxicol. Appl. Pharmacol.
; 180:22-35. (SCI) |
| 18. |
Lin C.-Y., Chen C.-S., Shieh M.-S., Wu C.-H.,
Lee H.-M. (2002) Development of an
automated immunoassay for advanced glycosylation end
products in human serum. Clin. Biochem . ,
35, (3): 189-195 (SCI) |
| 19. |
Chen C.-M., Wu C.-H., Lin C.-H., Chang C.-S.,
Lee H.-M. (2002) Involvement of
cAMP dependent protein kinase in BSA-AGEs-induced
iNOS expression and nitrite production in RAW 264.7
macrophages. New Taipei J. Med. 4:108-116. |
| 20. |
Chen M.-H., Lee H.-M., and Tseng
C.-Y. (2002) Polymorphism and heteroplasmy of
mitochondrial DNA in the D-loop region in Taiwanese.
J. Formos. Med. Assoc. 101:268-276.
(SCI) |
| 21. |
Lin C.-H., Kuan I.-H., Wanf C.-H., Lee H.-M
., Lee W..-S., Sheu J.-R., Hsiao G., Wu
C.-H., and Kuo H.-B.(2002) Lipoteichoic acid induced
cyclooxygenase-2 expression requires activation of
p42/44 and p38 MAPK signal pathways. Europ. J.
Pharmacol. 2002; 450:1-9 (SCI) |
| 22. |
Wu C.-H., Huang C.-M., Lin C.-H., Ho Y.-S.,
Lee H.-M. (2002) Induction of inducible
nitric oxide synthase expression by advanced
glycosylation end products in RAW 264.7 Macrophages:
involvement of Nuclear Factor-kappa B dependent
pathway. Mol. Cell. Endocrinol. (194) 9-17
(SCI) |
| 23. |
Kuo CS, Chiang LL, Lee CN, Yu MT, Pei KZ,
Lee HM , Lee WS, Sheu JR and Lin CH. (2003)
Induction of inducible nitric oxide synthase in RAW
264.7 macrophages by lipoteichoic acid derived from
Staphylococcus aureus: involvement of protein kinase
C- and nuclear factor-kB-dependent mechanisms.
J. Biomed. Sci. (10)136-145 (SCI) |
| 24. |
Wu C.-H., Chang C.-S., Lin C.-H., Lin S.-J., Chen
C.-M., Lee H.-M. (2003) Roles of
protein kinase C in BSA-AGEs mediated iNOS
expression in RAW264.7 macrophages. Biochem.
Pharmacol. (66)203-212 (SCI) |
| 25. |
Yang L.-L., Chang C.-W., Kuo C.-T., Wang C.-C.,
Lee H.-M. , Lin C.-H.(2003).Effects
of Sphondin, isolated from Heracluem laciniatum, on
IL-1-induced cyclooxygenase-2 expression in human
pulmonary epithelial cells. Life Sci.(72):199-213.
(SCI) |
| 26. |
Chiang LL., Kuo CT, Wang CH, Lee HM
, Ho YS, Kuo HP and Lin CH(2003).Involvement of
nuclear factor-kB in lipoteichoic acid-induced
macrophage cyclooxygenase-2 expression. J. Pharm.
Pharmacol .(55):1-7. (SCI) |
| 27. |
Chang P.C., Chen T-H, Chang C-J, Hou C-C,
Lee H.-M. (2004) Rosiglitazone Inhibits
Advanced Glycosylation End Product -Induced Nitric
Oxide Synthase Expression. Kidney Int. (65)
1664-1675 (SCI) |
| 28. |
Liu J.-C., Cheng T.-H., Lee H.-M .,
Lee W.S., Shih N.-L., Chen Y.-L., Chen J.-J., and
Chen P. (2004) Inhibitory effect of trilinolein on
angiotensin II-induced cadiomyocyte hypertrophy.
Europ. J. Pharmacol. (484) 1-8 (SCI) |
| 29. |
Liu J.-C., Chen P., Chen J.-J., Lee H.-M
., Lee W.S., Shih N.-L., Chen Y.-L., Cheng
T.-H., Hong H.J., Cheng T. H. (2004) The inhibitory
effect of trilinolein on norepinephrine-induced b
-myosin heavy chain promoter activity, reactive
oxygen species generation, and extracellular
signal-regulated kinase phosphorylation in neonatal
rat cardiomyocytes. J Biomed Sci (11) 11-18
(SCI) |
| 30. |
Chen T.-S., Wong C.-F., Chan P., and Lee H-M
(2004) Angiotensin II Increases Hypoxia
Inducible Factor-1 a Accumulation in Mesangial Cells
Through a Phosphatidylinositol 3-kinase Pathway.
Ann. N.Y. Acad Sci (In press) (SCI) |
| 31. |
Chen T.-H., Chang P.-C., Chang M.-C., Lin Y.-F. ,
Lee H.-M. (2004) Chloroquine
induced the expression of inducible nitric oxide
synthase in C6 glioma cells. Pharamacol. Res
. (In press) (SCI) |
| 32. |
Kao S.-H., Hung S.-L., Chen T.-S., and Lee
H-M (2004) Celecoxib Induces Heme
Oxygenase-1 Expression in Glomerular Mesangial Cells
via c-Jun-N-terminal kinase and Phosphatidylinositol
3-kinase dependent pathways. Ann. N.Y. Acad Sci
(In press) (SCI) |
| 33. |
Mau B.-L., Lee H.-M ., and Tzen C.Y.
(2004) Identification of Human-specific Adaptation
Sites of ATP6. Ann. N.Y. Acad Sci
(In press) (SCI) |
| 34. |
Lo M.-C., Lee H.-M., Lin M.W., and
Tzen C.Y. (2004) The Analysis of Heteroplasmy in the
Hypervariable Region II of Mitochondrial DNA in
Maternally Related Individuals. Ann. N.Y.
Acad Sci (In press) (SCI) |
| 35. |
Chen T.S. , Chen Y.-J., Chang M.-C., P. Chang, B-C.,
Hou, C-C., and Lee H-M (2004)
Dipyridamole induces apoptosis by inhibiting Akt
activation in rat mesangial cells. Acta
Nephrologica (In press) |
| 36. |
Chao H.-T., Lee S.-Y., Lee H-M .,
Liao T.-L., Wei Y.-H., Kao S.-H. (2004) Repeated
Ovarian Stimulations Induce Oxidative Damages and
Mitochondrial DNA Mutations in Mouse Ovaries.
Ann. N.Y. Acad Sci (In press) (SCI) |
| 37. |
Juan S.-H., JJ.-Y., Yen, Lee H-M .,
and Huang H.-M. (2004) IL-5 Inhibits Apoptosis by
Up-regulation of C-myc Expression in Human
Hematopoietic Cells. Ann. N.Y. Acad Sci (In
press) (SCI) |
| 38. |
38.
Chia CF, Chen SC, Chen CS,
Shih CM, Lee H-M, Wu CH(2005).Thallium
acetate induces C6 glioma cell apoptosis. Ann. N.Y.
Acad Sci.(1042):523-530. (SCI) |
| 39. |
Chen TH, Chang PC, Chang MC, Lin YF, Lee H-M
(2005).Chloroquine induced the expression of
inducible nitric oxide synthase in C6 glioma cells.
Pharamacol. Res.(51):329-336. (SCI) |
| 40. |
Kao SH, Hung SL, Chen TS, Lee H-M
(2005).Celecoxib Induces Heme Oxygenase-1 Expression
in Glomerular Mesangial Cells via c-Jun-N-terminal
kinase and Phosphatidylinositol 3-kinase dependent
pathways. Ann. N.Y. Acad Sci.(1042):235-245.
(SCI) |
| 41. |
Chen TS, Wong CF, Chan P, Lee H-M((2005).Angiotensin
II Increases Hypoxia Inducible Factor-1a
Accumulation in Mesangial Cells Through a
Phosphatidylinositol 3-kinase Pathway. Ann. N.Y.
Acad Sci.(1042):286-293. (SCI) |
| 42. |
Juan SH, Yen JY, Lee H-M, Huang HM(2005).IL-5
inhibits apoptosis by up-regulation og c-myc
expression in human hematopoietic cells. Ann. N.Y.
Acad Sci.(1042):481-487. (SCI) |
| 43. |
Chao HT, Lee SY, Lee H-M, Liao TL, Wei YH,
Kao SH(2005).Repeated ovarian stimulations induce
oxidative damage and mitochondrial DNA mutations in
mouse ovaries. Ann. N.Y. Acad Sci.(1042):148-156.
(SCI) |
| 44. |
Lo MC, Lee H-M, Lin MW, Tzen CY(2005).The
analysis of heteroplasmy in the hypervariable region
II of mitochondrial DNA in maternally related
individuals. Ann. N.Y. Acad Sci.(1042):130-135.
(SCI) |
| 45. |
Mau BL, Lee H-M, Tzen CY(2005).Identification
og human-specific adaptation sites of ATP6. Ann.
N.Y. Acad Sci.(1042):142-147. (SCI) |
| 46. |
Chen TH, Kao YC, Chen BC, Chen CH, Chan P, Lee
H-M (2006).Dipyridamole activation of mitogen-activated
protein kinase phosphatase-1 mediates inhibition of
lipopolysaccharide-induced cyclooxygenase-2
expression in RAW 264.7 cells. European Journal of
Pharmacology.(541):138-146. (SCI) |
| 47. |
Chen CH, Hsu YH, Sue YM, Hou CC, Lee H-M,
Huang HM, Chen TH(2006).Src homology 2-containing
phosphotyrosine phosphatase regulates
endothelin-1-induced epidermal growth factor
receptotransactivation in rat renal tubular cell
NRK-52Er. Pflug. Arch. Eur. J. Phy.(451):498-507.
(SCI) |
| 48. |
Chen TH, Hsu YT, Chen CH, Kao SH, Lee H-M
(2006).Tanshinone IIA from Salvia miltiorrhiza
Induces Heme Oxygenase-1 Expression and Inhibits
Lipopolysaccharide - Induced Nitric Oxide Expression
in RAW 264.7 Cells. Mitochondrion.(In pre):-.
(SCI) |
| 49. |
Shen SC, Lin CW, Lee H-M, Chien L, Chen
YC(2006).LPS plus TPA induction of migration and
invasion of glioma cells in vitro and in vivo:
differential inhibitory effects of flavonoids.
Neuroscience.(140):477-489. (SCI) |
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© 2008 School of
Medical Laboratory Science and Biotechnology |
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