Horng-Mo Lee Ph.D.
TEL:886-27361661 #3316

Highest Degree
Ph.D. from University of Tennessee, Memphis (1991)

   Signal transduction
Original paper: ( since 1997 )
01. Ho Y.-S., Lee H.-M , Mou T.-C. Wang I.-J. and Lin J.-K.(1997) Suppression of nitric oxide induced apoptosis by N-acetyl-L-cysteine through modulation of glutathione, Bcl-2 and bax protein levels. Mol. Carcinogene. 19:101-113. (SCI)
02. Lee H.-M and Huang C.L. (1997) NMDA inhibits carbachol-stimulated PI resynthesis. Neurochemical Research 22: 607-614. (SCI)
03. Pan S.H., Mou D.C., Huang C.L. and Lee H.-M. (1997) Pentoses react with BSA to form AGEs faster than hexoses in vitro. J. Chinese Nutrition Soc. 22: 193-205.
04. Pan S.H., Lin Y.H.,Su S.J.and Lee H.-M. (1997) Immunohistochemical localization of AGEs in tissues from STZ-induced diabetic rats. J. Biomed. Lab. Sci. 19: 78-86.
05. Lee, H.-M. , Tsai K.-J., Lin C.-H., Huang C.-L., amd Tung C.-S. (1998) Arecoline desensitizes carbachol-stimulated phosphatidylinositol breakdown in rat cortical slices. J. Neurochem. 70: 1189-1198. (SCI)
06. Ho Y.-S., Lee, H.-M. , Chang T.R., Wang Y-J., Lin J.-K. (1998) Induction of bax protein and degradation of lamin A during the p53-dependent apoptosis induced by chemotherapeutic agents in human cancer cells. Biochem. Pharmacol. 57:143-154. (SCI)
07. Lin Y.-F., Wang I.-K., Wu H.-S., Chen C.F., and Lee, H.-M. (1999) Elevation of serum advanced glycosylation end products in diabetic patients. New Taipei J. Med. 1:23-30.
08. Wu H.-S. and Lee, H.-M. (1999) Amphetamine activates protein kinase C in primary culture of rat brain neuronal cells. New Taipei J. Med. 1:12-19.
09. Chang S.-G., Chien C.-S., Lee H.-M . and Chen C.-Y. (1999) Interference of selected clinical medicines on DRU and TDx Immunoassay of morphine and metamphetamine in urine. J. Food & Drug Analysis. 7: 259-268. (SCI)
10. Chen C.-C., Huang C.-C., Chen F.-C., Lee H.-M ., Hsieh M.S. (2000) Factors influencing HbA1C analyses: Effects of anticoagulats and hematocrit. J. Biomed. Lab. Sci. 12: 20-24.
11. Lin C,-H., Sheu S.-Y., Lee H.-M . , Ho Y.-S., Lee W.-S., Ko W.-C., and Sheu J.-R. (2000) Involvement of PKC- g in IL-1 b induced Cox-2 expression in human pulmonary epithelial cells. Mol. Pharmacol. 57:36-43. (SCI)
12. Wang I.-K., Lin J.-K., Ho Y.-S., Yu W.-Y. and Lee H.-M . (2000) Roles of cyclin D3 in PMA-induced human leukemic HL-60 cell apoptosis. J. Genetics and Mol. Biol. 11: 1-11.
13. Lin C.-H., Kuan I. -H., Lee H.-M., Lee W.-S., Sheu J.-R., Ho Y.-S., Wang C-H., and Kuo H.-P. (2001). Induction of Cox-2 protein by LTA from Staphylococcus aureus in human pulmonary epithelial cells: Involvement of NFkB pathway. Br. J. Pharmacol. 134:543-552. (SCI)
14. Lin C.-H., Lin Y.-F., Chang M.-C., Ho Y.-S., and Lee H.-M . (2001) Advanced Glycosylation End Products -Induce Nitric Oxide Synthase Expression in C6 Glioma Cells: Involvement of p38 MAP kinase Dependent Mechanisms. Life Sci. 69:2503-2515. (SCI)
15. Lin C.-H., Wu C.-H., Thum W.-Y., Ho Y.-S., and Lee H.-M . (2002) Involvement of p38 MAP kinase in PLL-AGEs induced cyclooxygenase-2 expression in RAW 254.7 cells. Europ. J. Pharmacol. 2002; 438(3): 143-52. (SCI)
16. Chang M.-S., Lee W.-S., Teng C.-M., Lee H.-M ., Sheu J.-R., Hsiao G., Lin C.-H., (2002) YC-1 increases cyclooxygenase-2 expression through protein kinase G- and p42/44 mitogen activated protein kinase-dependent pathways in A549 cells. Brit. J. Pharmacol. (In press) (SCI)
17. Wu C.-H., Jeng J.-H., Wang Y.-J., Tseng C.-J., Liang Y.-C., Chen C.-H., Lee H.-M. Lin J.-K., Ho Y.-S. (2002) Antitumor effects of miconazole on human colon carcinoma xenograft in nude mice through induction of apoptosis and Go/G1 cell cycle arrest. Toxicol. Appl. Pharmacol. ; 180:22-35. (SCI)
18. Lin C.-Y., Chen C.-S., Shieh M.-S., Wu C.-H., Lee H.-M. (2002) Development of an automated immunoassay for advanced glycosylation end products in human serum. Clin. Biochem . , 35, (3): 189-195 (SCI)
19. Chen C.-M., Wu C.-H., Lin C.-H., Chang C.-S., Lee H.-M. (2002) Involvement of cAMP dependent protein kinase in BSA-AGEs-induced iNOS expression and nitrite production in RAW 264.7 macrophages. New Taipei J. Med. 4:108-116.
20. Chen M.-H., Lee H.-M., and Tseng C.-Y. (2002) Polymorphism and heteroplasmy of mitochondrial DNA in the D-loop region in Taiwanese. J. Formos. Med. Assoc. 101:268-276. (SCI)
21. Lin C.-H., Kuan I.-H., Wanf C.-H., Lee H.-M ., Lee W..-S., Sheu J.-R., Hsiao G., Wu C.-H., and Kuo H.-B.(2002) Lipoteichoic acid induced cyclooxygenase-2 expression requires activation of p42/44 and p38 MAPK signal pathways. Europ. J. Pharmacol. 2002; 450:1-9 (SCI)
22. Wu C.-H., Huang C.-M., Lin C.-H., Ho Y.-S., Lee H.-M. (2002) Induction of inducible nitric oxide synthase expression by advanced glycosylation end products in RAW 264.7 Macrophages: involvement of Nuclear Factor-kappa B dependent pathway. Mol. Cell. Endocrinol. (194) 9-17 (SCI)
23. Kuo CS, Chiang LL, Lee CN, Yu MT, Pei KZ, Lee HM , Lee WS, Sheu JR and Lin CH. (2003) Induction of inducible nitric oxide synthase in RAW 264.7 macrophages by lipoteichoic acid derived from Staphylococcus aureus: involvement of protein kinase C- and nuclear factor-kB-dependent mechanisms. J. Biomed. Sci. (10)136-145 (SCI)
24. Wu C.-H., Chang C.-S., Lin C.-H., Lin S.-J., Chen C.-M., Lee H.-M. (2003) Roles of protein kinase C in BSA-AGEs mediated iNOS expression in RAW264.7 macrophages. Biochem. Pharmacol. (66)203-212 (SCI)
25. Yang L.-L., Chang C.-W., Kuo C.-T., Wang C.-C., Lee H.-M. , Lin C.-H.(2003).Effects of Sphondin, isolated from Heracluem laciniatum, on IL-1-induced cyclooxygenase-2 expression in human pulmonary epithelial cells. Life Sci.(72):199-213. (SCI)
26. Chiang LL., Kuo CT, Wang CH, Lee HM , Ho YS, Kuo HP and Lin CH(2003).Involvement of nuclear factor-kB in lipoteichoic acid-induced macrophage cyclooxygenase-2 expression. J. Pharm. Pharmacol .(55):1-7. (SCI)
27. Chang P.C., Chen T-H, Chang C-J, Hou C-C, Lee H.-M. (2004) Rosiglitazone Inhibits Advanced Glycosylation End Product -Induced Nitric Oxide Synthase Expression. Kidney Int. (65) 1664-1675 (SCI)
28. Liu J.-C., Cheng T.-H., Lee H.-M ., Lee W.S., Shih N.-L., Chen Y.-L., Chen J.-J., and Chen P. (2004) Inhibitory effect of trilinolein on angiotensin II-induced cadiomyocyte hypertrophy. Europ. J. Pharmacol. (484) 1-8 (SCI)
29. Liu J.-C., Chen P., Chen J.-J., Lee H.-M ., Lee W.S., Shih N.-L., Chen Y.-L., Cheng T.-H., Hong H.J., Cheng T. H. (2004) The inhibitory effect of trilinolein on norepinephrine-induced b -myosin heavy chain promoter activity, reactive oxygen species generation, and extracellular signal-regulated kinase phosphorylation in neonatal rat cardiomyocytes. J Biomed Sci (11) 11-18 (SCI)
30. Chen T.-S., Wong C.-F., Chan P., and Lee H-M (2004) Angiotensin II Increases Hypoxia Inducible Factor-1 a Accumulation in Mesangial Cells Through a Phosphatidylinositol 3-kinase Pathway. Ann. N.Y. Acad Sci (In press) (SCI)
31. Chen T.-H., Chang P.-C., Chang M.-C., Lin Y.-F. , Lee H.-M. (2004) Chloroquine induced the expression of inducible nitric oxide synthase in C6 glioma cells. Pharamacol. Res . (In press) (SCI)
32. Kao S.-H., Hung S.-L., Chen T.-S., and Lee H-M (2004) Celecoxib Induces Heme Oxygenase-1 Expression in Glomerular Mesangial Cells via c-Jun-N-terminal kinase and Phosphatidylinositol 3-kinase dependent pathways. Ann. N.Y. Acad Sci (In press) (SCI)
33. Mau B.-L., Lee H.-M ., and Tzen C.Y. (2004) Identification of Human-specific Adaptation Sites of ATP6. Ann. N.Y. Acad Sci (In press) (SCI)
34. Lo M.-C., Lee H.-M., Lin M.W., and Tzen C.Y. (2004) The Analysis of Heteroplasmy in the Hypervariable Region II of Mitochondrial DNA in Maternally Related Individuals. Ann. N.Y. Acad Sci (In press) (SCI)
35. Chen T.S. , Chen Y.-J., Chang M.-C., P. Chang, B-C., Hou, C-C., and Lee H-M (2004) Dipyridamole induces apoptosis by inhibiting Akt activation in rat mesangial cells. Acta Nephrologica (In press)
36. Chao H.-T., Lee S.-Y., Lee H-M ., Liao T.-L., Wei Y.-H., Kao S.-H. (2004) Repeated Ovarian Stimulations Induce Oxidative Damages and Mitochondrial DNA Mutations in Mouse Ovaries. Ann. N.Y. Acad Sci (In press) (SCI)
37. Juan S.-H., JJ.-Y., Yen, Lee H-M ., and Huang H.-M. (2004) IL-5 Inhibits Apoptosis by Up-regulation of C-myc Expression in Human Hematopoietic Cells. Ann. N.Y. Acad Sci (In press) (SCI)

38. Chia CF, Chen SC, Chen CS, Shih CM, Lee H-M, Wu CH(2005).Thallium acetate induces C6 glioma cell apoptosis. Ann. N.Y. Acad Sci.(1042):523-530. (SCI) 

39. Chen TH, Chang PC, Chang MC, Lin YF, Lee H-M (2005).Chloroquine induced the expression of inducible nitric oxide synthase in C6 glioma cells. Pharamacol. Res.(51):329-336. (SCI)
40. Kao SH, Hung SL, Chen TS, Lee H-M (2005).Celecoxib Induces Heme Oxygenase-1 Expression in Glomerular Mesangial Cells via c-Jun-N-terminal kinase and Phosphatidylinositol 3-kinase dependent pathways. Ann. N.Y. Acad Sci.(1042):235-245. (SCI) 
41. Chen TS, Wong CF, Chan P, Lee H-M((2005).Angiotensin II Increases Hypoxia Inducible Factor-1a Accumulation in Mesangial Cells Through a Phosphatidylinositol 3-kinase Pathway. Ann. N.Y. Acad Sci.(1042):286-293. (SCI) 
42. Juan SH, Yen JY, Lee H-M, Huang HM(2005).IL-5 inhibits apoptosis by up-regulation og c-myc expression in human hematopoietic cells. Ann. N.Y. Acad Sci.(1042):481-487. (SCI) 
43.  Chao HT, Lee SY, Lee H-M, Liao TL, Wei YH, Kao SH(2005).Repeated ovarian stimulations induce oxidative damage and mitochondrial DNA mutations in mouse ovaries. Ann. N.Y. Acad Sci.(1042):148-156. (SCI)
44. Lo MC, Lee H-M, Lin MW, Tzen CY(2005).The analysis of heteroplasmy in the hypervariable region II of mitochondrial DNA in maternally related individuals. Ann. N.Y. Acad Sci.(1042):130-135. (SCI) 
45. Mau BL, Lee H-M, Tzen CY(2005).Identification og human-specific adaptation sites of ATP6. Ann. N.Y. Acad Sci.(1042):142-147. (SCI) 
46. Chen TH, Kao YC, Chen BC, Chen CH, Chan P, Lee H-M (2006).Dipyridamole activation of mitogen-activated protein kinase phosphatase-1 mediates inhibition of lipopolysaccharide-induced cyclooxygenase-2 expression in RAW 264.7 cells. European Journal of Pharmacology.(541):138-146. (SCI) 
47. Chen CH, Hsu YH, Sue YM, Hou CC, Lee H-M, Huang HM, Chen TH(2006).Src homology 2-containing phosphotyrosine phosphatase regulates endothelin-1-induced epidermal growth factor receptotransactivation in rat renal tubular cell NRK-52Er. Pflug. Arch. Eur. J. Phy.(451):498-507. (SCI) 
48. Chen TH, Hsu YT, Chen CH, Kao SH, Lee H-M (2006).Tanshinone IIA from Salvia miltiorrhiza Induces Heme Oxygenase-1 Expression and Inhibits Lipopolysaccharide - Induced Nitric Oxide Expression in RAW 264.7 Cells. Mitochondrion.(In pre):-. (SCI) 
49. Shen SC, Lin CW, Lee H-M, Chien L, Chen YC(2006).LPS plus TPA induction of migration and invasion of glioma cells in vitro and in vivo: differential inhibitory effects of flavonoids. Neuroscience.(140):477-489. (SCI)


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