Liang, Yu-Chih ,Ph.D.
TEL: 886-27361661 #3318

Highest Degree
Ph.D. Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan.

Molecular & Cellular Biology;
Signal transduction
Inflammatory research

Original paper: ( since 2004 )

1. Chen SH, Lin JK, Liang YC, Pan MH, Liu SH, Lin-Shiau SY. (2008) Involvement of activating transcription factors JNK, NF-kappaB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex. Eur J Pharmacol. 594(1-3):9-17.

2. Chang CC, Liu DZ, Lin SY, Liang HJ, Hou WC, Huang WJ, Chang CH, Ho FM, Liang YC# (2008) Liposome encapsulation reduces cantharidin toxicity. Food Chem Toxicol. 46(9):3116-21.

3. Liu Y, Wu J, Ho PY, Chen LC, Chen CT, Liang YC, Cheng CK, Lee WS. (2008) Anti-angiogenic action of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10). Cancer Lett. 2008 Jul 21. [Epub ahead of print]

4. Chen SH, Lin JK, Liu SH, Liang YC, Lin-Shiau SY (2008) Apoptosis of Cultured Astrocytes Induced by the Copper and Neocuproine Complex Through Oxidative Stress and JNK Activation. Toxicol. Sci., 102(1): 138-149.

5. Ho PY, Hsu SP, Liang YC, Kuo ML, Ho YS, Lee WS* (2008) Inhibition of the ERK phosphorylation plays a role in terbinafine-induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial cells. Toxicol. Appl. Pharmacol., 229(1):86-93.

6. Lin YC#, Liang YC#, Sheu MT, Lin YC, Hsieh MS, Chen TF and Chen CH* (2008) Chondroprotective effects of glucosamine involving the p38 MAPK and Akt signaling pathways. Rheumatol. Int., 28(10):1009-16.

7. Lu HT#, Liang YC#, Sheu MT, Ho HO, Lin YT, Hsieh MS, Chen CH* (2008) Disease-modifying effects of glucosamine hcl involving regulation of metalloproteinases and chemokines activated by interleukin-1β in human primary synovial fibroblasts. J. Cell. Biochem., 104(1):38-50.

8. Suk FM, Lin SY, Chen CH, Yen SJ, Su CH, Liu DZ, Hou WC, Hung LF, Lin PJ and Liang YC* (2008) Taiwanofungus camphorate activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats. Biosci. Biotechnol. Biochem., 72(7):1704-13.

9. Tsai SL, Suk FM, Wang CI, Liu DZ, Hou WC, Lin PJ, Hung LF, Liang YC* (2007)  Anti-tumor potential of 15,16-dihydrotanshinone I against breast adenocarcinoma through inducing G1 arrest and apoptosis. Biochem Pharmacol. 74(11):1575-86.

10. Lin YL, Liang YC, Chiang BL* (2007) Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. J. Leukoc. Biol. 82(6):1473-80.

11. Liu DZ, Liang HJ, Chen CH, Su CH, Lee TH, Huang CT, Hou WC, Lin SY, Zhong WB, Lin PJ, Hung LF and Liang YC* (2007) Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action. J. Ethnopharmacol., 113: 45-53.

12. Lo YJ, Sheu MT, Tsai WC, Lin YH, Li JL, Liang YC, Chang CC, Hsieh MS, Chen CH* (2007) Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis. Rheumatol Int. 27: 1099-111.

13. Liu DZ, Liang HJ, Chen CH, Lin SY, Zhong WB, Ho FM, Hou WC, Lo JL, Ho YS, Lin PJ, Hung LF and Liang YC* (2007) Switch activation of PI-PLC downstream signals in activated macrophages with wortmannin. BBA-Molecular Cell Research. 1773: 869–879.

14. Cheng HC, Chan CM, Tsay HS, Liang HJ, Liang YC, Liu DZ* (2007) Improving effects of epigallocatechin-3-gallate on hemorheological abnormalities of aging guinea pigs. Circ. J. 2007; 71: 597 – 603

15. Liu DZ, Liang YC, Lin SY, Lin YS, Wu WC, Hou WC, Su CH* (2007) Antihypertensive activities of a solid-state culture of Taiwanofungus camphoratus (chang-chih) in spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 71(1):23-30.


16. Chen CH, Sheu MT, Chen TF, Wang YC, Hou WC, Liu DZ, Chung TC and Liang YC* (2006) Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways. Biochem. Pharmacol., 72(8):1001-1009.

17. Zhong WB, Liang YC, Wang CY, Chang TC, Lee WS* (2005) Lovastatin suppresses invasiveness of anaplastic thyroid cancer cells by inhibiting Rho geranylgeranylation and RhoA/ROCK signaling. Endocr Relat Cancer. 12(3): 615-629.

18. Lin CM, Huang ST, Liang YC, Lin MS, Shih CM, Chang YC, Chen TY, Chen CT* (2005) Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages. Planta Med. 71(8): 748-753.

19. Chen SH, Liang YC, Chao JC, Tsai LH, Chang CC, Wang CC, Pan S* (2005) Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats. World J Gastroenterol. 11(24): 3746-3750.

20. Huang HM, Liang YC, Cheng TH, Chen CH, Juan SH* (2005) Potential mechanism of blood vessel protection by resveratrol, a component of red wine. Ann N Y Acad Sci. 1042: 349-356.

21. Yang KC, Uen YH, Suk FM, Liang YC, Wang YJ, Ho YS, Li IH, Lin SY* (2005) Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells. World J Gastroenterol. 11(20): 3040-3045.

22. Lin YL, Liang YC, Lee SS, Chiang BL* (2005) Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways. J Leukoc Biol. 78(2): 533-43.

23. Ho YS, Chen CH, Wang YJ, Pestell RG, Albanese C, Chen RJ, Chang MC, Jeng JH, Lin SY, Liang YC, Tseng H, Lee WS, Lin JK, Chu JS, Chen LC, Lee CH, Tso WL, Lai YC, Wu CH* (2005) Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation. Toxicol Appl Pharmacol. 205(2): 133-148.

24. Chou YH, Ho FM, Liu DZ, Lin SY, Tsai LH, Chen CH, Ho YS, Hung LF and Liang YC* (2005) The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1. Inter. J. Biochem. Cell Biol., 37:604-615.

25. Liang YC, Liu HJ, Chen SH, Tsai LH* (2005) Effect of lipopolysaccharide on the diarrhea and the gastrointestinal transit in mice: roles of nitric oxide and prostaglandin E2. World J. Gastroenter. 11: 357-361.

26. Liang YC, Wu CH, Chu JS, Wang CK, Hung LF, Wang YJ, Ho YS, Chang JG and Lin SY* (2005) Involvement of Fatty Acid-CoA Ligase 4 in Hepatocellular Carcinoma Growth: Roles of Cyclic AMP and p38 Mitogen-Activated Protein Kinase. World J. Gastroenter. 11: 2557-2563.

27. Liu JD, Tsai SH, Lin SY, Ho YS, Hung LF, Pan S, Ho FM, Lin CM and Liang YC* (2004) Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-D12,14- prostaglandin J2-induced heme oxygenase-1 expression. Life Sci., 74: 2451-2463.

28. Ho PY, Liang YC, Ho YS, Chen CT and Lee WS* (2004) Inhibition of human vascular endothelial cells proliferation by terbinafine. Inter. J. Cancer, 111: 51-59.

29. Shih CM, Lin H, Liang YC, Lee WS, Bi WF, Juan SH* (2004) Concentration-dependent differential effects of quercetin on rat aortic smooth muscle cells. Eur J Pharmacol. 496: 41-48.

30. Hsu YH, Hsieh MS, Liang YC, Li CY, Sheu MT, Chou DT, Chen TF, Chen CH* (2004) Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradation. J. Cell. Biochem. 93: 929-939.

31. Liao CH, Sang S, Liang YC, Ho CT, Lin JK* (2004) Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in downregulating nuclear factor-kappa B pathway by Garcinol. Mol. Carcinogenesis., 41: 140-149.

32. Shih CR, Wu J, Liu Y, Liang YC, Lin SY, Sheu MT and Lee WS* (2004) Anti-proliferation effect of 5,5-diphenyl-2-thiohydantoin (DPTH) in human vascular endothelial cells. Biochem. Pharmacol. 67: 67-75.

33. Yu CH, Wu J, Su YF, Ho PY, Liang YC, Sheu MT, Lee WS* (2004) Anti-proliferation effect of 3-amino-2-imino-3, 4-dihydro-2H-1,3-benzothiazin -4-one (BJ-601) on human vascular endothelial cells: G0/G1 p21-associated cell cycle arrest. Biochem Pharmacol. 67: 1907-1916.


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