Professor
   

Yuan-Soon Ho, Ph. D.
TEL:886-27361661 #3327
E-mailhoyuansn@tmu.edu.tw
 

Highest Degree
 
Ph. D. ( Biochemistry ), National Taiwan University, College of Medicine, Taipei, Taiwan

Specialties
Molecular Toxicology
Cancer cell biology
 
Original paper: ( since 2000 )
01. Ing-Kae Wang, Jen-Kun Lin, Yuan-Soon Ho, Wei-Yuan Yu, and Horng-Mo Lee. (2000) Roles of cyclin D3 expression in PMA-induced human leukemia cells (HL 60) apoptosis. Journal of Genetics and Molecular Biology 11(1), 1-11. ( SCI : impact factor 2.73 ,Toxicology 領域排名: 5/77
02. Rong-Jane Chen, Wen-Sen Lee, Yu-Chih Liang, Jen-Kun Lin, Ying-Jan Wang, Chien-Huang Lin, Jui-Ying Hsieh, Chiu-Chin Chaing, and Yuan-Soon Ho ( Correspondence ) (2000) Ketoconazole Induces G0/G1 Arrest in Human Colorectal and Hepatocellular Carcinoma Cell Lines. Toxicology and Applied Pharmacology 169: 132-141. ( SCI : impact factor 2.73 ,Toxicology 領域排名: 5/77
03. Wang YJ, Ho YS , Jeng JH, Su HC, Lee CC. (2000) Different cell death mechanisms and gene expression in human cells induced by pentachlorophenol and its major metabolite, tetrachlorohydroquinone. Chemical and Biological Interaction 128:173-188. ( SCI : impact factor 1.707 ,Toxicology 領域排名: 14/77
04. Jeng JH, Ho YS , Chan CP, Wang YJ, Hahn LJ, Lei D, Hsu CC, Chang MC. (2000) Areca Nut ExtractUp-Regulates Prostaglandin Production, Cyclooxygenase-2 mRNA and Protein Expression of Human Oral Keratinocytes. Carcinogenesis 21(7):1365-1370. ( SCI : impact factor 4.031 , Oncology 領域排名: 10/105
05. Chien-Huang Lin, Sheng-Yuan Sheu, Horng-Mo Lee, Yuan-Soon Ho, Wen-Sen Lee, Wun-Chang Ko and Joen-Rong Sheu. (2000) Involvement of protein kinase C- in IL-1 -induced cyclo-oxygenase-2 expression in human pulmonary epithelial cells. Molecular Pharmacology 57:36-43. ( SCI : impact factor 5.465 , Pharmacology 領域排名: 7/175
06. Chien-Huang Lin, Yuan-Fong Lin, Meng-Chu Chang, Yuan-Soon Ho, and Horng-Mo Lee (2001) Advanced glycosylation end products induce nitric oxide synthase expression in G6 glioma cells: involvement of a p38 MAP kinase-dependent mechanism. Life Science 69:2503-2515, (2001) (SCI : impact factor 1.808 , Pharmacology 領域排名: 36/181)
07. Chien-Huang Lin, I-Hui Kuan, Horng-Mo Lee, Wen-Sen Lee, Joen-Rong Sheu, Yuan-Soon Ho , Chun-Hua Wang and Han-Pin Kuo. (2001) Induction of cyclooxygenase-2 protein by lipoteichoic acid from Staphylococcus aureus in human pulmonary epithelial cells: involvement of a nuclear factor-kB-dependent pathway. British Journal of Pharmacology 134:543-552, 2001 (SCI : impact factor 3.7 , Pharmacology 領域排名: 15/175)
08. Shyr-Yi Lin, Yu-Tza Chang, Jeng-Dean Liu ,Chung-Hsun Tu , Yuan-Soon Ho , Yi-Hsuan Lee, and Wen-Sen Lee. (2001) Molecular mechanisms in apoptosis induced by magnolol in colon and liver. Molecular Carcinogenesis 32:73-83 (2001) (SCI : impact factor 3.104 , Oncology 領域排名: 30/105)
09. Chang MC, Ho YS , Lee PH, Chan CP, Lee JJ, Hahn LJ, Wang YJ and Jeng JH. (2001) Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells : association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogennesis 122(9):1527-1535, 2001 ( SCI : impact factor 4.031 ,Oncology 領域排名: 10/105
10. Chang MC, Ho YS , Lee JJ, Kok SH, Hahn LJ, Jeng JH. (2001) Prevention of the areca nut extract-induced unscheduled DNA synthesis of gingival keratinocytes by vitamin C and thiol compounds. Oral Oncology ( accepted ) ( SCI : impact factor 1.265 ,Dentistry,Oral surgery and medicine 領域排名: 12/45
11. Wang Y.J.,Lee C.C., cheng W.C.,Liou H.B. and Ho Y.S. ( Correspondence ) (2001) Oxidative stress and liver toxicity in rats and human hepatoma cell line induced by pentachlorophenol and its major metabolite tetrachlorohydroquinone. Toxicology Letter 122(2) : 157-169. ( SCI : impact factor 1.401 ,Toxicology 領域排名: 27/77
12. *Yuan-Soon Ho ( Correspondence ) Jiing-Shium Duh, Ying-Jan Wang, Yu-Chih Liang, Chien-Huang Lin, Jiiang-Huei Jeng, Chia-Jen Tseng, Cheng-Fei Yu,Rong-Jane Chen, and Jen-Kun Lin. (2001) Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells. International J of Cancer 91 : 393-401. ( SCI : impact factor 4.233 , Oncology 領域排名: 14/107
13. Ying-Jan Wang, Jiiang-Huei Jeng, Rong-Jane Chen, How Tseng, Li-Ching Chen, Yu-Chih Liang, Chien-Huang Lin, Chien-Ho Chen, Jan-Show Chu, Wei-Lu Ho,and Yuan-Soon Ho (Correspondence) . (2002) Ketoconazole potentiate the antitumor effects of nocodazole: in vivo therapy of human tumor xenografts in nude mice. Molecular Carcinogenesis 34(4):199-210 (SCI : impact factor 3.265 , Oncology 領域排名: 26/107)
14. Ying-Jan Wang Chen-Fei Yu, Li-Ching Cehn, Chien-Ho Chen, Jen-Kun Lin, Yu-Chih Liang, Chien-Huang Lin, Shyr-Yi-Lin, Chin Fa Chen, and Yuan-Soon Ho (Correspondence) . (2002) Ketoconazole potentiate terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. Journal of Cellular Biochemistry 87:147-159. (SCI : impact factor 2.536 , Biochemistry 領域排名: 113/305)
15. Chih-Hsiung Wu, Chao-Ming Huang Chien-Huang Lin, Yuan-Soon Ho , Chien-Ming Chen, and Horng-Mo Lee. (2002) Advanced glycosylation end product induced NF-kB dependent iNOS expression in RAW264.7 cells. Molecular and Cellular Endocrinology 194:9-17. (SCI : impact factor 2.404 , Emergency Medicine 領域排名: 35/90)
16. Shyr-Yi Lin, Yu-Chih Liang, Yuan-Soon Ho , Shu-Huei Tsai, Shiann Pan, and Wen-Sen Lee. (2002) Involvement of both extracellular signal regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-Acetate-induced upregulation of p21/Cip1 in colon cancer cells. Molecular Carcinogenesis 35(1):21-28. (SCI : impact factor 3.265 , Oncology 領域排名: 26/107)
17. Chang MC, HO YS, Lee JJ, Kok SH, Hahn LJ, Jeng JH. (2002) Prevention of the areca nut extract-induced unscheduled DNA synthesis of gingival keratinocytes by vitamin C and thiol compounds. Oral Oncology 38(3):258-265. (SCI : impact factor 1.606 , Dentistry 領域排名: 9/50)
18. Yuan-Soon Ho , Hung-Bin Liou, Jen-Kun Lin, Jiiang-Huei Jeng, Min-Hsiung Pan, Yu-Ping Lin How-Ran Guo, Sheng-Yow Ho, Ching-Chang Lee, and Ying-Jan Wang. (2002) Lipid peroxidation and cell death mechanisms in pulmonary epithelial cells induced by peroxynitrite and nitric oxide. Archives Toxicology 76(8):484-493. (SCI : impact factor 1.558 , Toxicology 領域排名: 31/78)
19. Chia-Jen Tseng, Ying-Jan Wang, Yu-Chih Liang, Jiiang-Huei Jeng, Wen-Sen Lee, Jen-Kun Lin, Chien-Ho Chen, I-Chun Liu, and Yuan-Soon Ho ( Correspondence ) . (2002) Microtubule Damaging Agents Induce Apoptosis in HL 60 Cell and G2/M Cell Cycle Arrest in HT 29 Cell Through Independent Signaling Pathway. Toxicology 175:123-142. (SCI : impact factor 1.752 , Toxicology 領域排名: 21/78)
20. Chih-Hsiung Wu, Jiiang-Huei Jeng, Ying-Jan Wang, Chia-Jen Tseng, Yu-Chih Liang, Chien-Ho Chen, Horng-Mo Lee, Jen-Kun Lin, Chien-Huang Lin, Shyr-Yi Lin, Chung-Pei Li, and Yuan-Soon Ho (Correspondence). ( 2002) Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest. Toxicology and Applied Pharmacology 180:22-35. ( SCI : impact factor 2.731 ,Toxicology 領域排名: 11/78
21. Chien-Huang Lin, Chih-Hsiung Wu, Wai-yee Thum, Yuan-Soon Ho , and Horng-Mo Lee. Involvement of p38 Mitogen-Activated Protein Kinase in PLL-AGEs-induced cyclooxygenase-2 expression in RAW 264.7 macrophages. European Journal of Pharmacology 438:143-152. (SCI : impact factor 2.164 , Pharmacology 領域排名: 50/186)
22. Chen-Ho Chen, Ling-Fang Huang, Li-Ching Chen, and Yuan-Soon Ho . (2002) Ketoconazole induces apoptosis through induction of Bax-signaling pathway in human prostate cancer cell lines. New Taipei Journal of Medicine. 4(3):159-166.
23. Yuan-Soon Ho , Jen-Kun Lin, Ling-Fang Huang, Shyr-Yi Lin, Shann Pan, and Yu-Chih Liang. (2002) Suppression of leukocyte adhesion molecules through inhibition of IkB kinase by tea polyphenols in human vascular endothelial cells. New Taipei Journal of Medicine. 4(3):1-6.
24. Fat-Moon Suk, Sheng-Hsuan Chen, Yuan-Soon Ho , Shiann Pan, Horng-Yuan Lou, Chun-Chao Chang, Ching-Ruey Hsieh, Yeong-Shan Cheng, Gi-Shih Lien. (2002) It is difficult to eradicate helicobacter Pylori from dental plaque by triple therapy. Chinese Medical Journal 65:468-473.
25. Liu JD, Lin SY, Ho YS , Pan S, Hung LF, Tsai SH, Lin JK and Liang YC (2003) Involvement of c-Jun N-terminal kinase activation in 15-deoxy- D 12,14 -prostaglandin J 2 and prostaglandin A 1 -induced apoptosis in AGS gastric epithelial cells. Mol. Carcinogenesis , In Press. (SCI : impact factor 3.265 , Oncology 領域排名: 26/107)
26. Wen-Sen Lee , , Rong-Jane Chen, Ying-Jan Wang, Jiiang-Huei Jeng, Yu-Chih Liang, Chien-Ho Chen, Chien-Huang Lin, Jen-Kun Lin, Pei-Yin Ho, Jan-Show Chu, Wei-Lu Ho, Li-Ching Chen, and Yuan-Soon Ho (Correspondence) (2003) In vitro and in vivo studies of the anti-cancer action of terbinafine in human cancer cell lines. International Journal of Cnacer (in press) ( SCI : impact factor 4.233 , Oncology 領域排名: 14/107
27. Jean-Dean Liu, Ying-Jan Wang, Chien-Ho Chen, Cheng-Fei Yu, Li-Ching Chen, Jen-Kun Lin, Yu-Chih Liang, Shyr-Yi Lin, and Yuan-Soon Ho (Correspondence) , (2003) Molecular mechanisms of G0/G1 cell cycle arrest and apoptosis induced by terfenadine in human cancer cells. Molecular Carcinogenesis. (in press) (SCI : impact factor 3.265 , Oncology 領域排名: 26/107)
28. Wen-Ching Chang, Jiiang-Huei Jeng, Chi-Chang Shieh, Yi-Chang Tsai, Yuan-Soon Ho , How-Ran Guo, Hsin-I Liu, Ching-Chang Lee, Sheng-Yow Ho, and Ying-Jan Wang. (2003) Molecular Carcinogenesis (In press) (SCI : impact factor 3.265 , Oncology 領域排名: 26/107)
29. Ho YS , Ma HY, Chang HY, Wei BL, Lee CC, Ho SY, Guo HR, Wu TP, Chang YJ, and Wang YJ. Lipid peroxidation and cell death mechanisms in rats and human cells induced by chloral hydrate. Food and Chemical Toxicology. 2003. (in press) ( SCI : impact factor 1.598 , Food Science and Technology 領域排名: 7/94
30. Ching LL, Kuo CT, Wang CH, Chen TF, Ho YS , Kuo HP, and Lin CH. Involvement of nuclear factor-kB in lipoteichoic acid-induced cyclooxygenase-2 expression in RAW 264.7 macrophages Journal of Pharmacy and Pharmacology 2003. 55:115-123. (SCI : impact factor, Oncology 領域排名: )
31. Lee YS, Lin CH, Hsu LW, Hu SY, Hsiao WT, and Ho YS. Role of ionotropic glutamate receptors in early developing neurons derived from the p19 mouse cell line. Journal of Biomedical Science (in press) (2003) (SCI : impact factor, Oncology 領域排名: )
32. Chiu-Po Chan, Yuan-Soon Ho, Ying-Jen Wang, Wan-Hong Lan, Lin-I Chen, Yi-Jane Chen, Bor-Ru Lin, Mei-Chi Chang, Jiiang-Huei Jeng, (2004) Inhibition of cyclooxygenase activity, platelet aggregation and thromboxane B2 production by two environmental toxicants: m-cresol and o-cresol. Toxicology (acepted) (SCI : impact factor 2.061, Toxicology field : 17/77)
33. Yuan-Soon Ho , Chien-Ho Chen, Ying-Jan Wang, Richard G. Pestell , Chris Albanese, Rong-Jane Chen, Mei-Chi Chang, Jiiang-Huei Jeng, Shyr-Yi Lin, Yu-Chih Liang, How Tseng, Wen-Sen Lee, Jen-Kun Lin, Jan-Show Chu, Li-Ching Chen, Chia-Hwa Lee, Wei-Ling Tso, Yann-Chwen Lai, and Chih-Hsiung Wu (2004) Tobacco specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NF k B activation and cyclin D1 upregulation. Toxicology and Applied Pharmacology 180:22-35. ( SCI : impact factor 2.851,Toxicology field : 10/77 )
34. Ho, P. Y. Liang, Y. C. Ho, Y. S. Chen, C. T. Lee, W. S. Inhibition of human vascular endothelial cells proliferation by terbinafine. International Journal of Cnacer 106:125-137. ( SCI : impact factor 4.375, Oncology field : 20/120 )
35. Wu, C. H. Chen, H. L. Su, H. J. Lee, C. C. Shen, K. T. Ho, W. L. Ho, S. Y. Ho, Y. S. Wang, Y. J. The topical application of 2,3,7,8-tetrachlorodibenzo-p-dioxin lacks skin tumor-promoting potency but induces hepatic injury and tumor necrosis factor-alpha expression in ICR male mice. Food and Chemical Toxicology. 2003. 41:621-629 ( SCI : impact factor 1.598, Food Science and Technology field : 7/94 )
36. Yang, K. C., Wu, C. C., Wu, C. H., Chen, J. H., Chu, C. H., Chien-Ho Chen, Chou Yean-Hwei, Ying-Jan Wang, Wen-(2005).Involvement of proapoptotic Bcl-2 family members in terbinafine-induced mitochondrial dysfunction and apoptosis in HL60 cells. Food and Chemical Toxicology.():-. 
37. Po-Hsuen Lee, Mei-Chi Chang, Wen-Hui Chang, Tong-Mei Wang, Ying-Jen Wang, Liang-Jiunn Hahn, Yuan-Soon Ho, Chuan-Yu Lin, Jiia(2005).Prolonged exposure to arecoline arrested human KB epithelial cell growth: regulatory mechanisms of cell cycle and apoptosis. Toxicology.():-.
38. Jinn-Shiun Chen,Shyr-Yi Lin,Wei-Ling Tso,Geng-Chang Yeh,Wen-Sen Lee,How Tseng, Li-Ching Chen, and Yuan-Soon Ho(2005).Checkpoint kinase 1-mediated phosphorylation of Cdc25C and Bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell cycle arrest and apoptosis. Molecular Carcinogenesis.():-. 
39. Jiiang-Huei Jeng, Wan-Hong Lan, Juo-Song Wang, Chiu-Po Chan, Yuan-Soon Ho, Po-Hsuen Lee, Ying-Jen Wang, Tong-Mei Wang, Yi-(2005).Signaling mechanism of thrombin-induced gingival fibroblast-populated collagen gel contraction. British Journal of Pharmacology.():-. 
40. Ho PY, Liang YC, Ho YS, Chen CT, Lee WS(2005).Inhibition of human vascular endothelial cells proliferation by terbinafine. International Journal of Cnacer.(106):125-137.
41. Chan PY, HO YS, Wang YJ, Lan WH, Chen LI, Yi-Jane Chen, Bor-Ru Lin, Mei-Chi Chang, Jiiang-Hu(2005).Inhibition of cyclooxygenase activity, platelet aggregation and thromboxane B2 production by two environmental toxicants: m-cresol and o-cresol. Toxicology.():-. 
42. Chiu-Po Chan, Yuan-Soon Ho, Ying-Jen Wang, Wan-Hong Lan, Lin-I Chen, Yi-Jane Chen, Bor-Ru Lin, Mei-Chi Chang, Jiiang-Hu(2005).Inhibition of cyclooxygenase activity, platelet aggregation and thromboxane B2 production by two environmental toxicants: m-cresol and o-cresol. Toxicology.(208):95-104. 
43. Meng-Shih Weng, Yuan-Soon Ho, Jen-Kun Lin(2005).Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: Involvement of p38 mitogen-activated protein kinase. Biochemical Pharmacology.(69):1815-1827. 
44. Yuan-Soon Ho,Chih-Hsiung Wu,Hsiao-Min Chou,Ying-Jan Wang,How Tseng,Chien-Ho ChenLi-Ching Chen, Chia-Hwa Lee, Shyr-Yi(2005).Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. Food and Chemical Toxicology.():-. 
45. Yuan-Soon Ho,Chien-Ho Chen,Ying-Jan Wang,Richard G. Pestell, Chris Albanese,Rong-Jane ChenMei-Chi Chang, Jiiang-Huei Jeng, Shy(2005).Tobacco specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NF羠 activation and cyclin D1 upregulation. Toxicology and Applied Pharmacology.(180):22-35.
46. Jinn-Shiun Chen,Shyr-Yi Lin,Wei-Ling Tso,Geng-Chang Yeh,Wen-Sen Lee,How Tseng, Li-Ching Chen, Yuan-Soon Ho*(2006).Checkpoint Kinase 1-Mediated Phosphorylation of Cdc25C and Bad Proteins Are Involved in Antitumor Effects of Loratadine-Induced G2/M Phase Cell-Cycle Arrest and Apoptosis. MOLECULAR CARCINOGENESIS.(45):461-478.
47. Po-Hsuen Lee, Mei-Chi Chang, Wen-Hui Chang, Tong-Mei Wang, Ying-Jen Wang, Liang-Jiunn Hahn, Yuan-Soon Ho*, Chuan-Yu Lin, Jii(2006).Prolonged exposure to arecoline arrested human KB epithelial cell growth: Regulatory mechanisms of cell cycle and apoptosis. Toxicology.(220):81-89. 
48. Kuo-Ching Yang, Chi-Chen Wu, Chih-Hsiung Wu, Jur-Hao Chen, Chien-Hwa Chu, Chien-Ho Chen, Yean-Hwei Chou, Ying-Jan Wang, Wen-(2006).Involvement of proapoptotic Bcl-2 family members in terbinafine-induced mitochondrial dysfunction and apoptosis in HL60 cells. Food and Chemical Toxicology.(44):214-226. 
49. Jiiang-Huei Jeng, Hui-Lin Wu, Bor-Ru Lin, Wan-Hong Lan, Hsiao-Hwa Chang, Yuan-Soon Ho, Po-Hsuen Lee, Ying-Jan Wang, Juo-Son(2006).Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production. Atherosclerosis.(44):214-226. 
50. Jeng, J. H., Lan, W. H., Wang, J. S., Chan, C. P., Ho, Y. S., Lee, P. H., Wang, Y. J., Wang, T. M., Chen, Y. J.,(2006).Signaling mechanism of thrombin-induced gingival fibroblast-populated collagen gel contraction. Br J Pharmacol.(147):188-198. 
51. How-Ran Guo, Chia-Hsin Chen, Sheng-Yow Ho, Yuan-Soon Ho, Rong-Jane Chen, Ying-Jan Wang(2006).Staurosporine modulates radiosensitivity and radiation-induced apoptosis in U937 cells. International Journal of Radiation Biology.(82):97-109. 
52. Pei-Yin Ho, Wen-Bin Zhong, Yuan-Soon Ho, Wen-Sen Lee(2006).Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway. Molecular Cancer Therapeutic.():-. 
53. Jiunn-Chang Lin, Yuan-Soon Ho, Jie-Jen Lee, Chien-Liang Liu, Tsen-Long Yang, Chih-Hsiung Wu(2006).Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine. Food and Chemical Toxicology.():-. 
54. Yuan-Soon Ho, Ching-Shu Lai, Hsin-I Liu, Sheng-Yow Ho, Chein Tai, Min-Hsiung Pan, Ying-Jan Wang(2006).Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation. Biochemical Pharmacology.():-. 
55. Tain-Junn Cheng, Ying-Jan Wang, Wei-Wan Kao, Rong-Jane Chen, Yuan-Soon Ho(2007).Protection against arsenic trioxide-induced autophagic cell death in U118 human glioma cells by use of lipoic acid. Food and Chemical Toxicology.():-. 
56. Yih-Huei Uen, Der-Zen Liu, Meng-Shih Weng, Yuan-Soon Ho, Shyr-Yi Lin(2007).NF-羠 pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL60 cells. J. Cellular Biochemistry.():-. 
 

 

© 2008 School of Medical Laboratory Science and Biotechnology