Associate Professor
　 　

Yi-Yuan Yang ,Ph.D.
TEL：886-27361661 #3325
E-mail：yangyuan@tmu.edu.tw
　

Highest Degree
　 　
Utah State University Ph.D.
　
Specialties
　
Virology and Immunology
　
Original paper： ( since 1992 )
01. Yang, Y.-Y. (1992). Epitopic mapping of serogroup and serotype specific proteins, VP7 and VP5, among five U.S. bluetongue viruses. Ph.D. dissertation, Utah State University, Logan, Utah, U.S.A.
02. Hwang, G-Y., Yang, Y.-Y., Chiou, J.-F. and Li, J.K.-K. (1992). Sequence conservation among the cognate nonstructural NS3/NS3A protein genes of six bluetongue viruses. Virus Research 23, 151-161.
03. Hwang, G-Y., Chiou, J.-F., Yang, Y.-Y. and Li, J.K.-K. (1992). Comparative sequences of the cognate structural protein VP6 genes of five U.S. bluetongue viruses. Virus Research 24, 315-323.
04. Yang, Y.-Y. and Li, J.K.-K. (1992). Complete genomic sequences of the GP5 protein gene of bluetongue virus serotypes 11 and 17. Virus Research 23, 163-171.
05. Yang, Y.-Y. , Chiou, J.-F., Hwang, G-Y., Huang, I.-J. and Li, J.K.-K. (1992). Sequences analysis of the cognate S2 gene encoding the nonstructural protein 2 (NS2) of five U.S. bluetongue viruses. Virus Research 25, 241-249.
06. Yang, Y.-Y. , Johnson, T., Mecham, J., Tam, J.P. and Li, J.K.-K. (1992). Epitopic mapping of the immunodominant linear and conformation-dependent antigenic determinants on GP5 of five U.S. bluetongue viruses. Virology 188, 530-536.
07. Singh, V.-K., Yang, Y.-Y. and Singh, E.-A. (1992). Immunoblot detection of antibodies to myelin basic protein in Alzheimer's disease patients. Neuroscience Letters 147, 25-28.
08. Hwang, G.-Y., Chiou, J.-F., Yang, Y.-Y. and Li, J.K.-K. (1993). High-sequence conservation among the United States bluetongue viruses cognate M2 genes which encode the nonstructural NS1 tubule protein. Virology 192, 321-327.
09. Yang, Y.-Y. and Li, J.K.-K. (1993) Glycosylation of the major outer capsid protein of bluetongue viruses. Virology 194, 350-354.
10. Fischer, P., Leu, S.-J., Yang, Y.-Y. and Chen, P.-P. (1994) Rapid simultaneous screening for DNA integrity and antigen specificity of clones selected by phage display. Biotechniques 16, 828-829.
11. Huang, I.-J., Hwang, G.-Y., Yang, Y.-Y. , Hayama, E. and Li, J.K.-K. (1995) Sequence analyses and antigenic epitope mapping of the putative RNA-directed RNA polymerase of five U.S. bluetongue viruses. Virology 214, 280-288.
12. Mo, L., Leu, S.-J., Berry, C., Liu, F., Olee, T., Yang, Y.-Y. , Beardsley, D.S., McMillan, R., Woods, V.L. Jr and Chen, P.-P. (1996) The frequency of homozygous deletion of a developmentally regulated Vh gene (Humhv3005) is increased in patients with chronic idiopathic thrombocytopenic purpura. Autoimmunity 24, 257-263.
13. Yang YY , Fischer P, Leu SJ, Olee T, Carson DA, Chen PP. IgG rheumatoid factors isolated by the surface-displaying phage library technique. Immunogenetics 1997; 45: 301-310.
14. Tsai SY, Chen KP, Yang YY , Chen CC, Lee JC, Leu SJ. Activation of cell-mediated immunity in manic episode of bipolar disorder. Taiwanese J Psychiatry 1998 ; 12(3): 207-217.
15. Yang YY , Fischer P, Leu SJ, Zhu M, Woods, Jr VL, Chen PP. Possible presence of enhancing antibodies in idiopathic thrombocytopenic purpura. British J Hematology 1999; 104: 69-80.
16. Tsai SY, Chen KP, Yang YY , Chen CC, Lee JC, Singh VK, Leu SJ . Activation of indices of cell-mediated immunity in bipolar mania. Biol Psychiatr y 1999; 45: 989-994.
17. Leu SJ, Tsai SY, Yang YY , Chou YM, Lee HC. Immune-inflammatory variables in acute manic episode of bipolar disorder. The International J Neuropsychopharmacology. (suppl.) 2000: S344.
18. Tsai SY, Yang YY , Kuo CJ, Chen CC, Leu SJ. Effects of symptomatic severity on elevation of plasma soluble interleukin-2 receptor in bipolar mania. J Affective Disorder 2001; 64:185-193.
19. 邱玉英，江春雪，謝文祥， 楊沂淵 . 市售核酸萃取試劑於臨床病毒檢驗應用上的比較 . J. Biomedical and Laboratory Sciences 2001; 13(3): S55-S60.
20. Yu-Ching Lee, Sy-Jye Leu, Ming-Song Hsieh, I-Jen Huang and Yi-Yuan Yang . Contribution of heavy chain genes on the binding property of a recombinant human IgG rheumatoid factor. J. Biomedical and Laboratory Sciences 2002; 14(4): 89-94.
21. Leu SJ, Tsai SY, Lin CY, Yang YY . Analysis of anti heat shock protein 60, 70, and 90 autoantibodies in patients with manic episode. (2002) The International J Neuropsychopharmacology. (suppl.)
22. Su KP, Leu SJ, Yang YY , Shen WW, Chou YM,.Tsai SYM. Reduced production of interferon-gamma but not interleukin-10 in bipolar mania and subsequent remission. J Affective Disorder (2002) 71:205-209.
23. Yu-Ying Chiu, Chun-Yan Yeung, Sy-Jye Leu, Wen-Shyang Hsieh, Ming-Song Hsieh, and Yi-Yuan Yang . Detection and investigation of TT virus infection in Taiwanese population. J. Biomedical and Laboratory Sciences 2003; 15(2): 27-34.
24. Liu HC, Yang YY , Chou YM, Chen KP, Shen WW, Leu SJ. Immunological variables in acute mania of bipolar disorder. J Neuroimmunol. 2004; 150, 116-122.
25. Yang YY, Hu CJ, Chang SM, Tsi TY, Leu SJ. Aspirin inhibits monocyte chemoattractant protein-1 and interleukin-8 expression in TNF-a stimulated human umbilical vein endothelial cells. Atherosclerosis 2004; 174, 207-213.
26. Hsueh-Hsia Wu, Wen-Shyang Hsieh, Yi-Yuan Yang, Ming-Chuan Tsai(2006).Lipoteichoic acid induces prostaglandin E2 release and cyclooxygenase-2 synthesis in rat cortical neuronal cells: Involvement of PKCε and ERK activation. Life Sciences.():272-280.
27. Lee YC, Leu SJC, Hu CJ, Shih NY, Huang IJ, Wu HH, Hsieh WS, Chiang BL, Chiu WT, Yang YY(2007).Chicken single-chain variable fragments against the SARS-CoV spike protein. Journal of Virological Methods.(146):104-111. 
28. Lee YC, Leu SJ, Hung HC, Wu HH, Huang IJ, Hsieh WS, Chiu WT, Hsieh MS, Cheng TF, Yang YY(2007).A dominant antigenic epitope on SARS-CoV spike protein identified by an avian single-chain variable fragment (scFv)-expressing phage. Veterinary Immunology and Immunopathology.(117):75-85.
29. Hsin-Chung Cheng, Hsin Chien, Chia-Hui Liao, Yi-Yuan Yang, Shih-Yi Huang(2007).Carotenoids Suppress Proliferating Cell Nuclear Antigen and Cyclin D1 Expression in Oral Carcinogenic Models. J of Nutritional Biochemistry.(18):667-675.
30. Lu HF, Liu JY, Hsueh SC, Yang YY, Yang JS, Tan TW, Kok LF, Lu CC, Lan SH, Wu SY, et al.,(2007).(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo. in vivo.(21):285-289. 
31. Chen KL, Liu WH, Yang YY, Leu SJ, Shih NY(2007).Characterization of novel transforming growth factor-beta type I. BMC Molecular Biology.(8):72-86. 
　 　

© 2008 School of Medical Laboratory Science and Biotechnology